Amines
1.0 Introduction
2.0 Preparation of Amines
2.1 Nucleophilic substitution
2.2 Reduction of Nitro Compounds
2.3 Reduction of Nitriles
2.4 Reduction of Amides
3.0 Physical Properties
4.0 Basic Nature of Amines
5.0 Reactions of Amines
5.1 Reaction of ${1^ \circ }$ and ${2^ \circ }$ amines with aldehydes and ketones
5.2 Acylation Reaction
5.3 Carbylamine Reaction
5.4 Reaction with Nitrous Acid
5.5 Substitution Reactions of Aryl Diazonium Salts
5.6 Electrophilic substitution reaction of Aniline
5.2 Acylation Reaction
2.2 Reduction of Nitro Compounds
2.3 Reduction of Nitriles
2.4 Reduction of Amides
5.2 Acylation Reaction
5.3 Carbylamine Reaction
5.4 Reaction with Nitrous Acid
5.5 Substitution Reactions of Aryl Diazonium Salts
5.6 Electrophilic substitution reaction of Aniline
Primary and secondary amines (both aliphatic and aromatic) react with acid chlorides, anhydrides and esters by nucleophilic substitution reaction. This reaction is known as acylation.
In this reaction, the replacement of hydrogen atom of $–NH_2$ or $-N–H$ group by the acyl group takes place to give amides as the products. It is carried out in the presence of a base stronger than the amine, like pyridine, which removes $HCl$ so formed and shifts the equilibrium to the right hand side.
Amines also react with benzoyl chloride $(C_6H_5COCl)$. This reaction is known as benzoylation.
