Amines
1.0 Introduction
2.0 Preparation of Amines
2.1 Nucleophilic substitution
2.2 Reduction of Nitro Compounds
2.3 Reduction of Nitriles
2.4 Reduction of Amides
3.0 Physical Properties
4.0 Basic Nature of Amines
5.0 Reactions of Amines
5.1 Reaction of ${1^ \circ }$ and ${2^ \circ }$ amines with aldehydes and ketones
5.2 Acylation Reaction
5.3 Carbylamine Reaction
5.4 Reaction with Nitrous Acid
5.5 Substitution Reactions of Aryl Diazonium Salts
5.6 Electrophilic substitution reaction of Aniline
2.4 Reduction of Amides
2.2 Reduction of Nitro Compounds
2.3 Reduction of Nitriles
2.4 Reduction of Amides
5.2 Acylation Reaction
5.3 Carbylamine Reaction
5.4 Reaction with Nitrous Acid
5.5 Substitution Reactions of Aryl Diazonium Salts
5.6 Electrophilic substitution reaction of Aniline
Amides on reduction with lithium aluminium hydride $(LiAlH_4)$ or catalytic hydrogenation produce primary, secondary or tertiary amines.
Hoffmann Bromamide degradation Reaction
A method for preparation of primary amines by treating an amide with bromine in an aqueous or ethanolic solution of sodium hydroxide.
In this degradation reaction, migration of an alkyl or aryl group takes place from carbonyl carbon of the amide to the nitrogen atom. The amine so formed contains one carbon less than that present in the amide.
